An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers.

نویسندگان

  • Aurore Fraix
  • Noufal Kandoth
  • Ilse Manet
  • Venera Cardile
  • Adriana C E Graziano
  • Ruxandra Gref
  • Salvatore Sortino
چکیده

A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.

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عنوان ژورنال:
  • Chemical communications

دوره 49 40  شماره 

صفحات  -

تاریخ انتشار 2013